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enVision 13(1)

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Cyclic AMP-dependent Protein Kinase

The balance between protein kinases and phosphatases plays a key role in regulating many cellular functions. Disturbing this balance can lead to disease or tumor formation. Cyclic AMP-dependent protein kinase (cAPK) was the first kinase to have its 3-D structure solved by X-ray crystallographic methods, and in many ways, cAPK is a paradigm for the entire kinase family. This VRML model from the MICE project highlights the cAPK functional units.