Dr. Jay Siegel and Dr. Kim Baldridge
UCSD Chemistry 245 Class
Structure and Properties of Organic Molecules
Instructors:
- Dr. Jay Siegel (University of California, San Diego)
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- Dr. Kim Baldrige (San Diego Supercomputer Center)
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Class syllabus:
This is an advanced graduate course on structural chemistry.
An excellent knowledge of basic Organic chemistry is expected.
We will cover the basic of structure-structure and structure-energy
relationships exemplified primarily by organic molecules. Topics to
be covered in this course are:
I. Introduction: Methods and Philosophy
- Kloppman-Salem Equations
- Basics of Structure-Correlation
- Basics of Empirical Force Fields
- Basics of PCModel
II. Orbital Interactions: Emphasis on Filled-Empty Orbital Interactions
- Chemical Bonding
- Aromaticity
- General Conjugation
- Sigma-Pi Conjugation
- Effect on Spectra
- Paracyclic Reactions
III. Effects Arising From Spatial Exclusion: Steric & Filled-Filled Orbital Interactions
- Acyclic Conformational Analysis
- Cyclic Conformational Analysis
- Models for Molecular Recognition
- Models for Stereoselective Interactions
IV. Charge Effects
- Coulombs Law
- Effects of Solvation