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For more than two decades, the San Diego Supercomputer Center (SDSC) has enabled ground-breaking science and engineering discoveries through advances in computational science and high performance computing. A key resource to academia and industry, SDSC provides leadership in Data Cyberinfrastructure, particularly with respect to data curation, management and preservation, data-oriented high-performance computing, and Cyberinfrastructure-enabled science and engineering. SDSC is an organized research unit of the University of California, San Diego and one of the founding sites of NSF's TeraGrid.

SDSC is housed in a building that sits on the campus at UC-San Diego and contains office space as well as a large machine room which houses the Center's compute and data resources.

On June 8, 2006, SDSC broke ground on an 80,000 square foot expansion of its building that will essentially double the size to nearly 160,000 gross square feet. The larger facility, scheduled for completion in late 2008, will also promote synergy by reuniting all of SDSC's 400 staff under one roof. In addition to offices and meeting rooms, the new expansion will incorporate a 250-seat auditorium that can be reconfigured into smaller spaces, research neighborhoods, a high-tech conference room with sophisticated teleconferencing gear and technology tools, and an advanced visualization lab. The expansion will add nearly 5,000 square feet of machine room space, bringing total machine room area to approximately 18,000 square feet.