Industrial Positions Available
Research Scientist (#26697), Bristol-Myers Squibb , Lawrenceville, NJ [11/18/08]
Scientist/Senior Scientist - Structure Biology, Plexxikon Inc., Berkeley, California [10/17/08]
Protein Crystallographer, Reciprocal Space Consulting LLC, Oakland, CA [08/20/08]
Director of Biological Sciences, Rational Labs Pvt. Limited, Hyderabad, India [08/20/08]
Research Associate/Sr. Research Associate, Locus Pharmaceuticals, Inc., Blue Bell, PA [07/31/08]
Associate Scientific Manager - Protein Crystallography , Syngene International, Bangalore,India [05/27/08]
Staff Scientist, Genzyme, 500 Kendall Street, Cambridge, MA 02142 [05/16/08]
Job ID 37527BR: Crystallography Research Scientist , Novartis Institutes for BioMedical Research, Cambridge, MA, USA [05/02/08]
Research Investigator , Novartis Institutes for BioMedical Research, Emeryville, California [03/16/08]
Senior R&D Engineer/Chemist w/ Crystallization, Honeywell, Colonial Heights, VA [03/05/08]
Senior R&D Engineer/Chemist w/ Crystallization, Honeywell, Colonial Heights, VA [03/05/08]
Research Associate - Protein Structure Group, Genentech, Inc., South San Francisco [02/07/08]
Bristol-Myers Squibb
Department: Analytical Research & Development
Location: Lawrenceville, NJ
URL: www.bms.com/career
Start Date: ASAP
Duration: Full Time
Description: Description: The successful candidate will work in a state of the art Solid State Chemistry laboratory housing two very bright rotating anode x ray generators each equipped with a single crystal and a powder diffractometer. As a member of a highly effective team, that provides crystallography collaboration in support of drug discovery and preclinical compound optimization, the candidate will be responsible for 1. Growing single crystals and assisting structure determination of discovery lead compounds and intermediates 2. Conducting powder diffraction experiments in support of crystallization efforts, formulation characterization, and single crystal studies 3. The alignment, calibration, and maintenance of the generators, single crystal or powder diffractometers, prompt and effective communication with vendors 4. Effective oral communication, timely written documentation, and data base entry of results. The candidate will also have the opportunity to develop cross site interactions with process chemists and pharmaceutical scientists and participate in the final form selection, salt and polymorph screening of Active Pharmaceutical Ingredients, API.
Requirements:A PhD, MS with 4 years of experience or BS with 7 years of experience level background in organic chemistry, engineering, x ray diffraction data collection, processing and analysis is sought. The candidate should have hands on experience with x ray diffraction equipment and with the crystallization of organic or inorganic materials. Experience in single crystal methods, including structure solution and refinement, is highly desirable. A working knowledge of physical characterization techniques, e.g. thermal analysis, microscopy, sorption analysis for chemical or pharmaceutical bulk solids is a plus. Good organizational, written and verbal communication skills as well as a demonstrated ability to work on a team are likewise essential. If interested, we invite you to apply online to www.bms.com/career and enter the requisition number 26697.
Other details: Bristol Myers Squibb is an equal opportunity employer M/F/D/V.
Please submit: Apply Online to www.bms.com/career with Req #26697
Person to contact: George Peterson
Email address: George.Peterson@bms.com
Job Posted: 11/18/08
Job ID Number: 1227024949
Plexxikon Inc.
Department: Structural Biology
Location: Berkeley, California
URL: www.plexxikon.com
Start Date: immediatly
Description: Located in Berkeley, California, Plexxikon is a leader in the discovery and development of novel small molecule pharmaceuticals to treat human disease. Since operations commenced June 2001, Plexxikon has applied its proprietary platform technology to identify and build a portfolio of product opportunities for therapeutic indications in metabolic disorders, cardiovascular disease, inflammation and oncology.
We are seeking a highly motivated and experienced X-ray protein crystallographer in our Structural Biology Department at the level of Scientist or Senior Scientist depending on qualifications. The successful candidate will participate in our scaffold-based drug discovery effort on many exciting therapeutic targets by carrying out high throughput co-crystal structure determination, co-crystallization and synchrotron data collection. The incumbent will play an important role in specific drug target project teams and collaborate closely with scientists from Molecular Biology, Protein Chemistry, Assay Development, Informatics and Chemistry in the discovery and optimization of novel drug candidates.
This position requires a PhD and, for Senior Scientist, a minimum of five years of industry experience in drug discovery. Qualified candidates must possess excellent communication skills and the ability to work in a highly collaborative and team oriented environment. In particular, the ability to effectively interface with chemistry and computational chemistry to facilitate drug design is highly desired. The ideal candidate will have a track record of accomplishments demonstrating technical proficiency, structural thinking, and scientific creativity. Extensive experience with high throughput co-crystal structure determination and high throughput co-crystallization are required. Experience with script writing and programming that facilitates automatic crystallographic structure determination and related tasks would be strongly desired.
If you are interested in applying for this opportunity, please submit your resume or CV, a cover letter and salary requirements to the address below. All submissions will be evaluated and interviews will be conducted for those applicants who most strongly fit our needs. If you are not contacted for an interview, your resume will remain on file and active for available positions for a period of one year.
Mail: Human Resources
Plexxikon Inc.
91 Bolivar Drive
Berkeley, California 94710
Fax: 510.647.4090
Email: careers@plexxikon.com
E-mailed resumes should be attached as Text or Word documents.
Plexxikon is an equal opportunity employer.
Please submit: CV and names of references
Person to contact: Human Resources
Surface mail address: Plexxikon Inc., 91 Bolivar Drive, Berkeley, California 94710
Email address: careers@plexxikon.com
Fax number: 510.647.4090
Job Posted: 10/17/08
Job ID Number: 1224282062
Reciprocal Space Consulting LLC
Location: Oakland, CA
URL: www.reciprocal-space-consulting.com
Start Date: immediate
Description: Exciting opportunity for a highly motivated protein crystallographer to join our team at Reciprocal Space Consulting in the San Francisco Bay area. Primary duties consist of measurement and analysis of protein diffraction data at the Advanced Light Source and the Stanford Synchrotron Radiation Laboratory and support of structure based drug design collaborations. The successful candidate will be a self starter with entrepreneurial skills and have extensive experience in all aspects of crystallography, including synchrotron data collection, data reduction software and beamline hardware. Candidate will have a Master’s degree with two years industrial experience or a Ph.D with two years of post-doctoral or industrial experience. Must be a U.S. citizen or permanent resident living in the Bay Area. Please send your CV and three references to HR@Reciprocal-Space-Consulting.com.
Please submit: CV and three references
Person to contact: Virginia Rath
Email address: HR@Reciprocal-Space-Consulting.com
Job Posted: 08/20/08
Job ID Number: 1219257867
Rational Labs Pvt. Limited
Department: Drug Discovery
Location: Hyderabad, India
Start Date: Open
Duration: Permanent
Description: Do you want to be part of an innovative drug discovery company utilizing state-of-the-art technology in a dynamic, challenging and fast-paced environment involved in developing small molecule drug candidates for major biotechs and multi-national pharmaceuticals. Explore this exciting opportunity. As Director of Biological Sciences you will be responsible for all the biological aspects of drug discovery including screening, target protein production, enzyme assays and in vitro characterization of compounds. Responsibilities include but not limited to building the Biological Sciences infrastructure, scientific team and managing and leading. In this capacity you will involved in strategic decision making for all the drug discovery programs, internal and external.
Qualifications:
• 5 – 10 years experience in an industrial/academic setup, including a minimum of 3 years in a managerial/supervisory capacity is desirable.
• Experience of having managed drug discovery programs as part of a matrix team.
• Extensive experience with designing and generating multiple constructs to be cloned into E. coli and insect cell (Baculovirus) expression systems is a must.
• Strong knowledge and hands on experience in optimizing expression conditions for producing drug targets for screening and crystallographic studies in sufficiently pure and large quantities using Baculovirus and E. coli expression systems.
• Strong background in purification of tagged and non-tagged proteins using chromatographic techniques.
• Deep insight as to needs of protein requirements for generating diffraction quality crystals for structure based drug discovery programs.
• Experience in developing assays for measuring IC50s, EC50s and related parameters for in vitro screening.
• Excellent written and oral communication skills, capable of presenting the company’s Biological Sciences capabilities to potential collaborators and partners.
• Strong commitment to deliver results and high quality data on aggressive time lines.
Your qualifications and experience will be awarded with an excellent compensation package which includes benefits, annual performance bonus and ownership in the company in form of incentive stock options. You will be working in a dynamic environment with the best management team in the area of drug discovery with opportunity to develop skills for your professional growth. In return we expect strong long term commitment and dedication to build and grow a strong and successful organization.
If you meet the above requirements and have a passion for working in a challenging environment and need to be considered seriously, please submit your resume/CV with names and addresses of three references to:
Please submit: Resume/CV and Names and address of three references
Person to contact: Mr. Naresh Arrera
Surface mail address: Rational Labs Pvt. Limited, Plot No. 177, IDA, Mallapur, Hyderabad 500 076, India
Email address: contact@rationallabs.com
Fax number: +91 402-715-4587
Job Posted: 08/20/08
Job ID Number: 1219249195
Locus Pharmaceuticals, Inc.
Department: Structure Biology Dept.
Location: Blue Bell, PA
URL: locuspharma.com
Start Date: ASAP
Description: Locus Pharmaceuticals, Inc. is a world leader in fragment-based, computational drug design. We have combined highly integrated chemistry, crystallography and biology capabilities to create a unique drug design and development platform for oral drug therapies in areas of unmet need.
All of our development programs emanate from our proprietary computational technology and have been directed primarily in cancer and inflammation. The most advanced program is in Phase I human testing for cancer and two additional programs are in late stage preclinical development.
Locus Pharmaceuticals has an immediate opening for a highly motivated and enthusiastic Research Associate to join Structural Biology Group.
Duties:
The successful candidate will be primarily responsible for purification, characterization, and crystallization of proteins for structural determination. The work includes development of novel purification protocols as well as optimization of existing protein purification strategies and crystallizing proteins in the presence or absence of small molecule ligands. The qualified individual should be able to work independently but collaboratively with a varied group of scientists.
Skills:
· Expertise in the area of protein purification and characterization with experience in a crystallography highly preferred.
· Experience with and understanding of ion exchange, gel filtration, HIC, affinity and reverse phase chromatography required.
· Broad experience with a variety of biochemical methods for protein characterization (protein quantitation, protein modification strategies, cross linking, limited proteolysis) is desirable.
· Excellent instrument skills including the use of AKTA systems required.
The successful candidate will be highly organized, able to work independently when necessary, have the ability to effectively collaborate within multidisciplinary teams, and possess good communication skills.
Education:
BS or MS in biochemistry, chemistry or related discipline
Please submit: CV
Person to contact: Susan Litte - Sr. Director, HR
Email address: slittle@locuspharma.com
Job Posted: 07/31/08
Job ID Number: 1217523242
Syngene International
Department: Biology
Location: Bangalore,India
URL: http://www.biocon.com/syngene.asp
Start Date: 27/05/2008
Description: This individual will be expected to complete computation crystallography activities including refinement of protein ligand complexes and detailed annotation of the resulting structures.
Other details: Previous experience with COOT, CCP4 or equivalent tools is essential. The candidate should also have a strong interest in drug discovery, a customer-oriented attitude towards scientific colleagues, demonstrated scientific creativity and excellent English communication skills
Please submit: CV,3 references,relocation plans to India
Person to contact: Gautam
Email address: gautham.hebbar@syngeneintl.com
Phone number: 91 80 280839
Job Posted: 05/27/08
Job ID Number: 1211877246
Genzyme
Department: Drug and Biomaterial R&D
Location: 500 Kendall Street, Cambridge, MA 02142
URL: www.genzyme.com
Start Date: June 1, 2008
Description: Genzyme Corporation, ranked as one of the foremost biotechnology companies in the world, is committed to providing an exceptional environment in which individuals can excel, and achieve their professional and personal goals. Genzyme Corporation has been selected by FORTUNE magazine as one of the "100 Best Companies to Work For in 2006 in the United States”. By applying for a position with Genzyme, you are taking the first step toward becoming a part of our dynamic and talented team, and sharing in our continued success.
Job Responsibilities:
We are seeking a skilled and motivated Scientist to join our Fragment Based Drug Design (FBDD) efforts for small molecule drug discovery. The scientist will be involved in all aspects of the fragment screening process from compound management to reporting data. The application of new technologies for solving drug discovery problems will be a strong component for this position. Additionally, you will participate in protein purification efforts for supplying target enzymes and substrates for screening.
Basic Qualifications:
Ph.D. in Biochemistry/Chemistry/Biophysics with 3 years experience including: 1 year of experience in biophysical and biochemical assay development, 1 year experience with the use of SPR and/or calorimetry for investigating protein /ligand binding interactions and 1 year experience in structural characterization of protein / ligand complexes through x-ray crystallography.
Preferred Qualifications:
Drug Discovery Experience, and in particular, some Affinity Based Ligand Screening experience. Biophysical Chemistry, Structural Biology and Protein Sciences experience. Preferred biophysical tools and skill sets include: (1) Surface Plasmon Resonance (SPR) technologies (Biacore, etc.); (2) Calorimetric tools such as Isothermal Titrating Calorimetry (ITC) and Differential Scanning Calorimetry (DSC); (3) Affinity Based Ligand Screening; (4) Protein Crystallography. Strong communication and collaborative skills are desired for effective integration with other members of the FBDD team from Chemistry, Biology, Protein Sciences, and Structural Biology.
Other details: Please apply online at: www.Genzyme.com/careers job number 12699
Person to contact: Bob Hale
Surface mail address: 55 Cambridge Parkway, Cambridge, MA 02142
Email address: bob.hale@genzyme.com
Job Posted: 05/16/08
Job ID Number: 1210951661
Novartis Institutes for BioMedical Research
Department: Protein Structure
Location: Cambridge, MA, USA
URL: http://jobs.brassring.com/EN/ASP/TG/cim_advsearch.asp?partnerid=13617&siteid=5050
Start Date: ASAP
Description: Job Description:
The candidate will join a the protein structure unit and will contribute to the implementation of state-of-the-art technologies. The candidate will also be an integral member of structure-based drug design teams and will lead independent protein crystallography studies. The candidate’s primary responsibilities will be the determination of de novo protein structures, determination of structures of protein ligand complexes, and participation in the interpretation and use of the results with multi-disciplinary drug discovery teams.
Minimum requirements:
Ph.D. or equivalent with at least 2 years of post-doctoral experience in protein crystallography with demonstrated success in all aspects of protein crystallography required (e.g. crystallization, refinement, phasing techniques). Experience with membrane protein expression, purification, and crystallization is required. Strong communication skills with the ability to work in large, multidisciplinary drug discovery teams is essential.
Other details: Novartis is committed to embracing and leveraging diverse backgrounds.
Novartis is an equal opportunity employer M/F/D/V.
Please use this link (http://jobs.brassring.com/EN/ASP/TG/cim_advsearch.asp?partnerid=13617&siteid=5050)and search for Job ID 37527BR to apply.
Please submit: Resume and Cover letter via website
Job Posted: 05/02/08
Job ID Number: 1209757738
Novartis Institutes for BioMedical Research
Department: Structural Chemistry
Location: Emeryville, California
URL: www.novartisvaccines.com/jobs
Start Date: ASAP
Duration: Not applicable
Description: Structural Chemistry, Structure-Based Drug Design & Discovery
Novartis Institutes for BioMedical Research, Emeryville, California
Use your scientific expertise to aid us in our structure-based drug design efforts. Your task will be the determination of high-resolution, three-dimensional structures of macromolecular drug targets (typically proteins), including crystallization and structure solution of medically important structures and target-ligand complexes. As a part of an integrated team you will interact with computational chemists and medicinal chemists to design new scaffolds and improve lead compounds. The ideal candidate will have an M.S. degree and 7 or more years of work experience or a Ph.D. and 3-6 years of postdoctoral and/or work experience. Degrees in Biochemistry, Chemistry, or Molecular Biophysics are acceptable. Strong experience in protein biochemistry and crystallographic methods is necessary and pharmaceutical industry experience is a plus. Strong computational and molecular modeling skills, experience in solution studies (calorimetry, NMR, etc.), experience in structure-based drug design, and/or expertise in complex crystallization problems would be useful. You should have excellent verbal and written communication skills and the ability to work in large, multidisciplinary project teams.
To join our global team, please submit your CV online at http://www.novartisvaccines.com/jobs , referencing Brassring requisition number 2294.
Any questions about the position should be sent to dirksen.bussiere@novartis.com.
Please submit: CV and list of 3 references
Person to contact: Dirksen Bussiere
Surface mail address: 4560 Horton St., M/S 4.4, Emeryville, CA. 94608
Email address: dirksen.bussiere@novartis.com
Phone number: 510-923-2114
Fax number: 510-923-5550
Job Posted: 03/16/08
Job ID Number: 1205696518
Honeywell
Department: Research Center
Location: Colonial Heights, VA
URL: www.honeywell.com/careers/jobsearch.html
Start Date: ASAP
Description: Our Business: Honeywell Resins & Chemicals
Honeywell’s Resins and Chemicals business within the Specialty Materials division offers a robust product portfolio and manufacturing capabilities to a wide variety of customers worldwide. Products include the nylon feedstock caprolactam and other chemicals, ammonium sulfate fertilizers and specialty polymers.
RESPONSIBILITIES:
- Propose and develop new concepts for caprolactam, ammonium sulfate and related compound crystallization.
- Lead product and process development efforts including pilot programs.
- Design and build laboratory scale apparatus and supervise experimental operations.
- Supervise technicians, maintain laboratory facilities and implement new equipment and procedures.
- Support existing fertilizer manufacturing and customer applications world-wide.
BASIC QUALIFICATIONS:
- MS/PhD. in chemical engineering with experience in crystallization and precipitation processes.
ADDITIONAL QUALIFICATIONS:
- Strong understanding for developing process engineering scopes for new processes a plus.
- Requires experience with experimental design and statistical analysis.
- Experience with industrial solution crystallization a big plus.
- Background in product development a plus.
- Six Sigma training a plus.
- Ability to plan and lead projects essential.
- Modeling experience a plus
- Familiarity with methods development a plus.
- Experience using Excel, MSWord and PowerPoint.
- Programming experience in Basic or FORTRAN a plus.
- Experience building small scale reactors in glassware and/or in metal.
- Experience with basic statistics.
- Background in basic analytical chemistry a plus.
- Excellent communication and documentation skills.
- Bias for action and results oriented mindset.
- Technical competence: statistical, analytical, mechanical, chemical and computer skills
- Ability to work both independently, and in team environments.
Location: Colonial Heights, VA. Relocation assistance available.
As an Equal Opportunity Employer, we are committed to a diverse workforce.
Please submit: CV/Resume
Person to contact: George Boncelet
Surface mail address: 101 Columbia Road, Morristown, NJ 07962
Email address: george.boncelet@honeywell.com
Phone number: 973-455-4813
Fax number: 973-455-4797
Job Posted: 03/05/08
Job ID Number: 1204730217
Honeywell
Department: Research Center
Location: Colonial Heights, VA
URL: www.honeywell.com/careers/jobsearch.html
Start Date: ASAP
Description: Our Business: Honeywell Resins & Chemicals
Honeywell’s Resins and Chemicals business within the Specialty Materials division offers a robust product portfolio and manufacturing capabilities to a wide variety of customers worldwide. Products include the nylon feedstock caprolactam and other chemicals, ammonium sulfate fertilizers and specialty polymers.
RESPONSIBILITIES:
- Propose and develop new concepts for caprolactam, ammonium sulfate and related compound crystallization.
- Lead product and process development efforts including pilot programs.
- Design and build laboratory scale apparatus and supervise experimental operations.
- Supervise technicians, maintain laboratory facilities and implement new equipment and procedures.
- Support existing fertilizer manufacturing and customer applications world-wide.
BASIC QUALIFICATIONS:
- MS/PhD. in chemical engineering with experience in crystallization and precipitation processes.
ADDITIONAL QUALIFICATIONS:
- Strong understanding for developing process engineering scopes for new processes a plus.
- Requires experience with experimental design and statistical analysis.
- Experience with industrial solution crystallization a big plus.
- Background in product development a plus.
- Six Sigma training a plus.
- Ability to plan and lead projects essential.
- Modeling experience a plus
- Familiarity with methods development a plus.
- Experience using Excel, MSWord and PowerPoint.
- Programming experience in Basic or FORTRAN a plus.
- Experience building small scale reactors in glassware and/or in metal.
- Experience with basic statistics.
- Background in basic analytical chemistry a plus.
- Excellent communication and documentation skills.
- Bias for action and results oriented mindset.
- Technical competence: statistical, analytical, mechanical, chemical and computer skills
- Ability to work both independently, and in team environments.
Location: Colonial Heights, VA. Relocation assistance available.
As an Equal Opportunity Employer, we are committed to a diverse workforce.
Please submit: CV/Resume
Person to contact: George Boncelet
Surface mail address: 101 Columbia Road, Morristown, NJ 07962
Email address: george.boncelet@honeywell.com
Phone number: 973-455-4813
Fax number: 973-455-4797
Job Posted: 03/05/08
Job ID Number: 1204730183
Genentech, Inc.
Department: Protein Engineering
Location: South San Francisco
URL: www.gene.com/careers
Start Date: asap
Description: For more than 30 years, Genentech has been at the forefront of the biotechnology industry, using human genetic information to develop novel medicines for serious and life-threatening diseases. Today, Genentech is among the world's leading biotech companies, with multiple therapies on the market for cancer and other unmet medical needs. Please take this opportunity to learn about Genentech, where we believe that our employees are our most important asset.
The following opportunity exists in our South San Francisco, CA facility:
Research Associate-Protein Engineering
We have an opportunity for a talented research associate to join the protein structure group involved in exploring structure and functional properties of proteins of therapeutic interest. The successful candidate will be primarily responsible for purification, characterization, and crystallization of proteins for structural determination. The work includes developing and optimizing protein purification strategies, crystallizing proteins in the presence or absence of ligands, while contributing both to small molecule discovery programs and basic research projects.
Requirements: BS or MS in Biochemistry, Chemistry or a related discipline. Prefer three or more years of technical experience in areas related to protein chemistry, along with experience in a structural biology group highly. Must be motivated and capable of working independently, in addition to enjoying working in a collaborative setting. Strong analytical, communication and organization skills are also required.
Genentech is dedicated to fostering an environment that is inclusive and encourages diversity of thought, style, skills and perspective. To learn more about all of our current opportunities, please visit: www.gene.com/careers and reference Req #1000020713. Please use GENE when a "source" is requested. Genentech is an Equal Opportunity Employer.
Job Posted: 02/07/08
Job ID Number: 1202415300
Last posting: 11/18/08Problems? Send mail to aca@sdsc.edu.