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SDSC's Baru cited in Nature article

Geneticists study chimp human divergence

Published 03/24/2004

SAN DIEGO - - Scientists combing the draft of the chimpanzee genome sequence are finding tantalizing hints about the differences between humans and our closest relatives.

Results gleaned from the publicly available genome, which was released last December, were discussed for the first time at a workshop on 12 March at the University of California, San Diego.

Researchers led by Xose Puente at the University of Oviedo in Spain, for example, are working on genes that encode enzymes called proteases. These genes are almost identical in humans and chimps except for one subset, found in the immune system, that varies greatly between the two species.

This suggests proteases of the immune system diverged rapidly after chimps and humans became separate species. Such findings could help to clarify the differences between the two species. They could also explain why chimps are less severely affected than humans by AIDS or Alzheimer's disease, and might lead to treatments for such conditions.

Evan Eichler, a bioinformaticist at Case Western Reserve University in Cleveland, Ohio, found one section of DNA, 10,000 bases long, that is absent in the human genome but present in multiple copies in the chimpanzee and other African apes. By sequencing that section, Eichler's lab found that it was similar to a retrovirus that infects African monkeys. Because retroviruses insert themselves into host DNA, Eichler suspects that this virus might have jumped from monkeys into apes.

But experts say that such topics are hard to study, in part because there are still large gaps in the sequenced chimp genome. Reassuringly, Robert Waterston, a geneticist at the University of Washington in Seattle who leads an international team studying the chimp genome, says that the US National Human Genome Research Institute will provide funding for sequencers to keep plugging the gaps.

Further help in studying chimp and human differences will come from molecular biologist Ajit Varki and computer scientist Chaitan Baru, both at the University of California, San Diego. They plan to collate details of all the characteristics that differ between chimps and humans on a web-based Museum of Comparative Anthropogeny (MOCA). They hope that MOCA will help to reveal how the 1% of the genome that differs between humans and chimps has translated into the huge differences between the two species in areas such as brain size and behaviour.

But biologist Caroline Tutin of the University of Stirling in Scotland warns that, although the differences are illuminating, geneticists should not overlook the similarities between humans and chimps. "Do not forget how similar the chimp and human are, because that is the basis for their conservation," Tutin says. She warns that as wild populations of endangered chimps dwindle, scientists risk losing a species that is not only a precious genetic resource, but a close relative as well.