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Understanding Parkinson's Disease

Parkinson's disease destroys brain tissue, impairing motor skills and speech. Abnormal deposits of the protein alphasynuclein are thought to be a cellular-level culprit. By modeling how alpha-synuclein can form pore-like structures such as the pentamer in this image, which lead to neural death, Igor Tsigelny and his colleagues at SDSC and UCSD have gained fresh insights that can help researchers better fight this devastating disease. In research supported by the NIH and DOE, computations for the study were performed on SDSC's Blue Gene supercomputer and resources at Argonne National Laboratory.
Credit: I. Tsigelny, Y. Sharikov, M. Miller, and E. Masliah, SDSC/UCSD.
Source: San Diego Supercomputer Center, UC San Diego

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