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Learning about Lipids

A detailed understanding of lipids, the fat-like, hydrophobic molecular components of cells, sheds light on new lipid associated pathways and helps design drugs to combat heart disease and other disorders involving lipid metabolism. Scientists use the saccharolipid "KDO2-lipid A" (shown) to stimulate a macrophage cell via the Toll-like receptor 4 (TLR4), and measure the response of other lipids to this signaling event. In the NIGMS Lipid MAPS (metabolism and pathways strategy) Consortium, experimental data from several core centers is integrated in a "lipidomics" database at SDSC and made available at The bioinformatics and systems biology components are directed by Shankar Subramaniam, Professor of Bioengineering and Chemistry and Biochemistry in UCSD's Jacobs School of Engineering.
Courtesy of S. Subramaniam, M. Sud, E. Fahy, A. Maer, UCSD/SDSC. Image: B. Tolo.
Source: San Diego Supercomputer Center, UC San Diego

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