The overall goal of the Alliance for Cellular Signaling (AfCS)
is to understand as completely as possible the relationships between
sets of inputs and outputs in signaling cells that vary both temporally
and spatially. The same goal, stated from a slightly different perspective,
is to understand fully how cells interpret signals in a context-dependent
manner. The primary responsibility of the AfCS Bioinformatics Laboratory
at SDSC is the analysis and dissemination of data generated by the
AfCS experimental labs. I will describe the steps that are required
to go from raw experimental data to an interactive display that is
useful to biologists. I will also touch on some of the secondary data
analysis being carried out at SDSC. A second major activity of our
laboratory is the development of the Molecule Page database containing
information on approximately 3000 proteins that are of importance
to signal transduction. I will provide an overview and describe both
the automated and author-entered aspects of the Molecule Page project.
The San Diego Supercomputer
Center (SDSC) is a research unit of the University of California,
San Diego, and the leading-edge site of the National Partnership for
Advanced Computational Infrastructure. SDSC researchers conduct studies
in computational science, develop high-performance computing and networking
technologies, and participate in NPACI activities.