Andrew D. McCulloch
Professor of Bioengineering
University of California San Diego amcculloch@ucsd.edu
Experimental and Computational Modeling of Cardiac
Electromechanical Interactions
There is a close and complex coupling between the electrical and mechanical
activity of the heart. Dysregulation of these interaction mechanisms
is associated with chronic cardiac pathologies and can be life threatening.
Our objective is to develop biophysically detailed, structurally based
computational models that integrate cardiac electromechanics from
the molecular scale to that of the organ. Such models require experimental
validation. I'll present some recent computational and experimental
results that illustrate this approach.
The San Diego Supercomputer
Center (SDSC) is a research unit of the University of California,
San Diego, and the leading-edge site of the National Partnership for
Advanced Computational Infrastructure. SDSC researchers conduct studies
in computational science, develop high-performance computing and networking
technologies, and participate in NPACI activities.