Home > Archives > Additional Archives > Daniel Fischer   Daniel Fischer Bioinformatics, Dept. of Computer Science Ben Gurion University, Israel dfischer@cs.bgu.ac.il http://www.cs.bgu.ac.il/~dfischer/  Finding Families for Genomic ORFans: The Role of Bioinformatics in Structural and Functional Genomics The recent determination of the complete genome sequences of organisms allows us to study protein function, structure and evolution from a perspective not available before. In the lack of experimental characterization for the vast majority of the proteins encoded in these genomes, computational approaches can be applied to help to interpret the enormous amount of raw sequence data. In this talk I focus on those ORFs which can not be placed into known sequence, functional or structural families with current methods. I refer to these ORFs as orphan-ORFs or ORFans for short. ORFans correspond to genomic regions which are yet to be interpreted, and can be classified into sequence, functional and structural ORFans, respectively. ORFans pose interesting challenges to both experimentalists and computational biologists in the post-genomic era. I will present my view of how in-silico approaches can help to meet some of these challenges by complementing and extending experimental structural and functional genomics studies.
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