Home > Archives > Additional Archives > Keith Dunker   Keith Dunker Department of Biochemistry Washington State University dunker@wsuvm1.csc.wsu.edu http://www.chem.wsu.edu/dunker.html/   Abstract: The Protein Trinity: Linking Function With Intrinsic Disorder Proteins have been shown to exist in 3 forms: the ordered state (solid-like), the partially folded state (molten globule-like or liquid-like) and the extended state (random coil-like or gas-like). The Protein Trinity Hypothesis has two components: 1. a given native protein can be in any one of the 3 forms for which sequence not solvent determines folding, incomplete folding or lack of folding; and 2.function can arise from any one of the three forms or transitions between them. About 20 specific examples will be presented in support of this hypothesis, and predictions will be discussed indicating that the Protein Data Bank is highly biased against native disorder. These results have serious implications for structural genomics and related issues such as drug discovery.
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