Date/Time/Place: September 30, 2004, 1-2 pm, SDSC Auditorium

Speaker: Sandra Orchard
EMBL – European Bioinformatics Institute

Title: UniProt 2.0 and the annotation of Protein Kinases

Abstract: A tour through the functionality of UniProt 2.0 will be provided with particular reference to annotation of members of the Protein Kinase family, one of the largest, and arguably best conserved protein families – members of which can be found in species as diverse as man and bacteria.

The Swiss-Prot, TrEMBL and PIR protein databaseactivities have united to form the Universal Protein Knowledgebase(UniProt) consortium, to provide a comprehensive,fully classified, richly and accurately annotated protein sequenceknowledgebase, with extensive cross-references and query interfaces.The central database will has two sections, corresponding tothe familiar Swiss-Prot (fully manually curated entries) andTrEMBL (enriched with automated classification, annotation andextensive cross-references). For convenient sequence searches, UniProt also provides several non-redundant sequence databases.The UniProt NREF (UniRef) databases provide representative subsetsof the knowledgebase suitable for efficient searching. The comprehensiveUniProt Archive (UniParc) is updated daily from many publicsource databases and includes many predicted and synthetic sequences which are not appropriate for inclusion within UniProt. A tour through the functionality of UniProt 2.0 will be provided with particular reference to annotation of members of the Protein Kinase family, one of the largest, and arguably best conserved protein families – members of which can be found in species as diverse as man and bacteria.

UniProt: www.pir.uniprot.org