Analysis of Cancer Tissue by Complex DNA and Antibody Microarrays

The Division of Functional Genome Analysis at the DKFZ is involved in the development of technologies for the analysis of large genomic areas to entire genomes with respect to the encoded functions and their regulation. Based on technical advances, various functional aspects are being analysed. One emphasis is work on DNA-, protein- and peptide-microarrays. Apart from addressing chemical and biophysical issues, the resulting methods are immediately put to the test in relevant, biologically driven projects on various organisms. Concerning analysis of human material, systems are being developed toward early diagnosis, prognosis and evaluation of the success of disease treatment with accentuation on cancer.

Beside a variety of other applications, comparative studies on transcription levels, actual protein expression and epigenetic variation are under way.
http://www.dkfz-heidelberg.de/funct_genome/index.html